The Tumor Necrosis Factor-α Converting Enzyme (TACE): A Unique Metalloproteinase with Highly Defined Substrate Selectivity
نویسندگان
چکیده
منابع مشابه
Expression of tumor necrosis factor-_ converting enzyme (TACE) in endocrine cancers
(2008) Expression of tumor necrosis factor [alpha] converting enzyme in endocrine cancers. ABSTRACT Tumor necrosis factor-_ converting enzyme (TACE) mediates shedding of human epidermalgrowth factor receptor-4 (HER4). Recent data suggests that released HER4 intracellulardomain (4ICD) induces apoptosis in breast cancer.TACE expression, as measured by immunohistochemistry, was observed in 183/383...
متن کاملThe growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE).
Proteolysis of the GHR (growth hormone receptor) occurs at the cell surface and results in the release of its extracellular domain, the GHBP (growth hormone-binding protein). TACE (tumour necrosis factor-alpha-converting enzyme) has been identified as a putative protease responsible for GHR cleavage. However, GHR-TACE interaction has not been observed until now. Here, we identified TACE in Chin...
متن کاملMonocyte Tumor Necrosis Factor-α–Converting Enzyme Catalytic Activity and Substrate Shedding in Sepsis and Noninfectious Systemic Inflammation*
OBJECTIVES To determine the effect of severe sepsis on monocyte tumor necrosis factor-α-converting enzyme baseline and inducible activity profiles. DESIGN Observational clinical study. SETTING Mixed surgical/medical teaching hospital ICU. PATIENTS Sixteen patients with severe sepsis, 15 healthy volunteers, and eight critically ill patients with noninfectious systemic inflammatory response...
متن کاملExpression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis.
OBJECTIVES We determined whether tumor necrosis factor-alpha-converting enzyme (TACE) is expressed with tumor necrosis factor-alpha (TNF-alpha) in myocarditis. BACKGROUND Tumor necrosis factor-alpha-converting enzyme, which has recently been identified as belonging to the family of metalloproteinase disintegrin proteins, is responsible for the conversion of TNF-alpha precursor to its mature f...
متن کاملP2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production
Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain as a soluble cytokine. The purinergic receptor P2X ligand-gated ion channel 7 (P2X7) is activated in response to elevated concentrations of ext...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemistry
سال: 2003
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi033012g